SARS-CoV-2 Zeta variant

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Zeta variant, also known as lineage P.2,^[a] is a variant of SARS-CoV-2, the virus that causes COVID-19. It was first detected in the state of Rio de Janeiro; it harbors the E484K mutation, but not the N501Y and K417T mutations. It evolved independently in Rio de Janeiro without being directly related to the Gamma variant from Manaus.^[1][2]

Under the simplified naming scheme proposed by the World Health Organization, P.2 was labeled "Zeta variant", and was considered a variant of interest (VOI), but not a variant of concern.^[3] A second wave was preceded in November 2020 by an increase in the prevalence of the Zeta variant among genetic sequences from São Paulo state, deposited into the GISAID database.^[4] As of July 2021, Zeta is no longer considered a variant of interest by the WHO.^[5]

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